Chemical Structure : GSK223
CAS No.:
899758-61-3
GSK223
(GSK-223)
Catalog No.: PC-49811Not For Human Use, Lab Use Only.
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase.
GSK223 does not inhibit any kinase against a panel of 300 kinases.
GSK223 inhibits Tri-DAP -stimulated IL-8 secretion (IC50=1 uM) in HCT116 colon carcinoma cells which endogenously express both NOD proteins at functional levels, with minimal or no inhibition of MDP-stimulated NOD2 signaling.
GSK223 (0.1-10 uM) antagonized the Tri-DAP induced increase in p-JNK levels and reduction in IκBα in 293/hNOD1 cells in a concentration-dependent manner, no effect on the same responses to MDP in 293/hNOD2 cells at >30 uM.
Physicochemical Properties
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M.Wt
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443.51
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Formula
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C21H18FN3O3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-ethyl-N-(2-fluoro-5-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenyl)thiophene-2-sulfonamide
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References
1. David J Rickard, et al. PLoS One. 2014 May 7;9(5):e96737.
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