Catalog No.: PC-35385Not For Human Use, Lab Use Only.
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.
INF39 significantly inhibit ATP- and nigericin-induced IL-1β release in mouse bone marrow derived macrophages (BMDM) at 10 uM.
INF39 reduces colonic myeloperoxidase, IL-1β, and TNF Levels in DNBS-treated rats.
Physicochemical Properties
M.Wt
224.684
Formula
C12H13ClO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Ethyl 2-(2-chlorobenzyl)acrylate
References
1. Cocco M, et al. J Med Chem. 2017 May 11;60(9):3656-3671.
