INF39 | NLRP3 inhibitor | Probechem Biochemicals

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Chemical Structure : INF39

CAS No.: 866028-26-4

INF39 (NLRP3 inhibitor INF39)

Catalog No.: PC-35385Not For Human Use, Lab Use Only.

INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$298	In stock
50 mg	$458	In stock
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Biological Activity

INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages.
INF39 significantly inhibit ATP- and nigericin-induced IL-1β release in mouse bone marrow derived macrophages (BMDM) at 10 uM.
INF39 reduces colonic myeloperoxidase, IL-1β, and TNF Levels in DNBS-treated rats.

Physicochemical Properties

M.Wt	224.684
Formula	C12H13ClO2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 2-(2-chlorobenzyl)acrylate

References

1. Cocco M, et al. J Med Chem. 2017 May 11;60(9):3656-3671.

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INF39 (NLRP3 inhibitor INF39)

Biological Activity

Physicochemical Properties

References

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