Chemical Structure : NOD1 antagonist 66
CAS No.:
NOD1 antagonist 66
Catalog No.: PC-23602Not For Human Use, Lab Use Only.
NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively.
Compound 66 exhibits high selectivity over NOD2, RIP2, TLR2, TLR4 and TLR9.
Compound 66 antagonizes C12-iE-DAP-induced NF-κB activation.
Compound 66 suppresses inflammation via NOD1 activation, inhibits NOD1-Induced NF-κB and MAPK pathways.
Compound 66 blocks C12-iE-DAP activation of NOD1 signaling and H. pylori-mediated inflammatory cytokine.
Compound 66 ((12.5, 25, and 50 mg/kg), oral) inhibited C12-iE-DAP-induced and H. pylori infection inflammatory responses in mice.
Physicochemical Properties
|
M.Wt
|
560.37
|
|
Formula
|
C21H13Cl2F2N3O5S2
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
N-(2-Chloro-5-(2-chloro-6-(methylsulfonyl)-4-oxoquinazolin-3(4H)-yl)phenyl)-2,6-difluorobenzenesulfonamide
|
References
1. Liu X, et al. J Med Chem. 2024 Dec 5. doi: 10.1021/acs.jmedchem.4c02139.
Contact Us
sales@probechem.com
