ASP0965 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : ASP0965

ASP0965 (ASP-0965)

Catalog No.: PC-23679Not For Human Use, Lab Use Only.

ASP0965 is potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with IC50 of 8.4 nM (in vitro IL-1β inhibitory activity).

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Biological Activity

ASP0965 is potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with IC50 of 8.4 nM (in vitro IL-1β inhibitory activity).
ASP0965 also shows potent inhibition of ASC speck formation in THP-1 cells stimulated by LPS/ATP with IC50 of 5.7 nM.
ASP0965 significantly inhibits the production of IL-1β at 0.3, 1, and 3 mg/kg doses in rat cerebrospinal fluid (CSF).
ASP0965 shows a dose-dependent inhibition on α-synuclein-dependent IL-1β production in THP-1 cells with IC50 of 6.3 nM.
ASP0965 (10-mg/kg, qd) improves motor function in α-synuclein injection model.

Physicochemical Properties

M.Wt	381.40
Formula	C19H22F3N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(6-{[(1R,2R)-2-Hydroxycyclohexyl]amino}-4,5-dimethylpyridazin-3-yl)-5-(trifluoromethyl)phenol

References

1. Inagaki Y, et al. Bioorg Med Chem. 2024 Dec 12;118:118042.

ASP0965 (ASP-0965)

Biological Activity

Physicochemical Properties

References

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