YM-I-26

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Chemical Structure : YM-I-26

Catalog No.: PC-23200Not For Human Use, Lab Use Only.

YM-I-26 is a highly selective NLRP3 inflammasome inhibitor, binds to recombinant NLRP3 with Kd of 560.2 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YM-I-26 is a highly selective NLRP3 inflammasome inhibitor, binds to recombinant NLRP3 with Kd of 560.2 nM.
YM-I-26 preferentially binds to the ATP site of NLRP3.
YM-I-26 shows no cytotoxicity and increases the phagocytotic activities in BV2 cells.
YM-I-26 treatment (0.5-1 uM) suppressed the production of IL-1β and IL-10 in microglia BV2 cells.

Physicochemical Properties

M.Wt	577.15
Formula	C28H33ClN2O5S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-2-propoxybenzyl)-N-(4-(morpholinosulfonyl)phenethyl)-2-(thiophen-3-yl)acetamide

References

1. Ma A, et al. J Med Chem. 2014 Aug 14;57(15):6822-33.

2. Xu Y, et al. Eur J Med Chem. 2022 Aug 5;238:114468.

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YM-I-26

Biological Activity

Physicochemical Properties

References

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