INF195 | NLRP3 inhibitor | Probechem Biochemicals

Chemical Structure : INF195

INF195 (INF 195, INF-195)

Catalog No.: PC-22763Not For Human Use, Lab Use Only.

INF195 is a small molecule NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis and IL-1 β release in human macrophages.

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Biological Activity

INF195 is a small molecule NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis and IL-1 β release in human macrophages.
INF195 does not inhibit TNF-α release from human macrophages.
INF195 (5-10 uM) significantly reduces both infarct size and IL-1β levels
INF195 protect mice hearts after myocardial IRI in ex vivo heart model.

Physicochemical Properties

M.Wt	323.82
Formula	C17H22ClNO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 1-(3-(2-chlorophenyl)propanoyl)piperidine-3-carboxylate

References

1. Gastaldi S, et al. Vascul Pharmacol. 2024 Jun 17;156:107397.

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INF195 (INF 195, INF-195)

Biological Activity

Physicochemical Properties

References

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