| Cat. No. |
Product Name |
Information |
| PC-24821 |
PKUMDL-LC-102
GPX4 activator
|
PKUMDL-LC-102 is a selective, allosteric small molecule GPX4 activator (150% activation at 39.2 μM), shows no activity against COX-1, COX-2, mPGES-1, 5-LOX, LTA4H, 12-LOX, and 15-LOX. |
| PC-24567 |
CuATSM
ferroptosis inhibitor, SOD1 modulator
|
CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity. |
| PC-24537 |
DEL-I25
GPX4 R152H activator
|
DEL-I25 is a selective, small molecule activator of GPX4 R152H variant, selectively binds to GPX4 R152H (MST binding KD, 2 uM), restores GPX4R152H enzyme activity, and specifically rescues patient-derived lymphoblast cells. |
| PC-24078 |
Ferfluor-1
Ferroptosis inhibitor
|
Ferfluor-1 is a potent, selective ferroptosis inhibitor, rescues ferroptotic cell death on HT1080 cells with EC50 of 57 nM, also is a specific ferroptosis photoluminescence imaging probe. |
| PC-23010 |
Salinomycin
Ferroptosis inducer
|
Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-22833 |
NCOA4-FTH1 inhibitor 9a
NCOA4-FTH1 inhibitor
|
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| PC-22475 |
BCP-T.A
Ferroptosis inducer
|
BCP-T.A is a potent ferroptosis inducer by binding to GPX4 with IC50 of 17 nM in ferroptosis sensitive cell line NCI-H522. |
| PC-21713 |
GPX4 inhibitor A16
GPX4 inhibitor
|
GPX4 inhibitor A16 is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM. |
| PC-20924 |
FerroLOXIN-2
Ferroptosis inhibitor
|
FerroLOXIN-2 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo. |
| PC-20923 |
FerroLOXIN-1
Ferroptosis inhibitor
|
FerroLOXIN-1 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo. |
