| Cat. No. |
Product Name |
Information |
| PC-60374 |
FIN56
Ferroptosis inducer
|
FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4. |
| PC-42089 |
RSL3
GPX4 inhibitor, Ferroptosis inducer
|
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM). |
| PC-42286 |
Piperazine Erastin
Ferroptosis inducer
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
| PC-45261 |
Salinomycin sodium
Ferroptosis inducer
|
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-26934 |
GPX4 inhibitor C18
GPX4 inhibitor
|
GPX4 inhibitor C18 (GPX4-IN-5) is a covalent inhibitor of glutathione peroxidase 4 (GPX4), shows remarkable inhibitory activity against TNBC cells with IC50 of 10-75 nM. |
| PC-26804 |
FXT-003
Ferroptosis inhibitor
|
FXT-003 is a highly potent, effective, orally bioavailable next-generation ferroptosis inhibitor with IC50 of 11.7 nM in HT-1060 cells. |
| PC-26803 |
FXT-002
Ferroptosis inhibitor
|
FXT-002 is a highly potent, effective, oral;y bioavailable next-generation ferroptosis inhibitor with IC50 of 6.91 nM in HT-1060 cells. |
| PC-26704 |
ARVib-7
NDUFS4 inhibitor
|
ARVib-7 is a small molecule inhibitor of NDUFS4, a nuclear-encoded subunit of electron transport chain complex I, disrupts OxPhos and induces ferroptosis. |
| PC-25538 |
Deferoxamine mesylate
Iron chelator, Ferroptosis inhibitor
|
Deferoxamine mesylate (DFOM) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. |
| PC-25537 |
Deferoxamine
Iron chelator, Ferroptosis inhibitor
|
Deferoxamine (DFO) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. |
| PC-25428 |
Ferritinophagy inhibitor 4k
Ferroptosis inhibitor
|
Ferritinophagy inhibitor 4k is a specific inhibitor of ferritinophagy, disrupt the interaction of NCOA4 and ferritin, inhibits RSL3-induces ferroptosis with IC50 of 520 nM in HT-1080 cells. |
| PC-24932 |
Acevaltrate
Ferroptosis inducer
|
Acevaltrate is a novel ferroptosis inducer and dual inhibitor of PCBP1/2 and GPX4, also inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. |
