| Cat. No. |
Product Name |
Information |
| PC-27626 |
4-Hydroxynonenal
ALDH2 substrate, Ferroptosis inducer
|
4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4. |
| PC-24821 |
PKUMDL-LC-102
GPX4 activator
|
PKUMDL-LC-102 is a selective, allosteric small molecule GPX4 activator (150% activation at 39.2 μM), shows no activity against COX-1, COX-2, mPGES-1, 5-LOX, LTA4H, 12-LOX, and 15-LOX. |
| PC-24537 |
DEL-I25
GPX4 R152H activator
|
DEL-I25 is a selective, small molecule activator of GPX4 R152H variant, selectively binds to GPX4 R152H (MST binding KD, 2 uM), restores GPX4R152H enzyme activity, and specifically rescues patient-derived lymphoblast cells. |
| PC-22833 |
NCOA4-FTH1 inhibitor 9a
NCOA4-FTH1 inhibitor
|
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| PC-22532 |
SRS 16-86
Ferroptosis inhibitor
|
SRS16-86 is a potent inhibitor of ferroptosis. |
| PC-22475 |
BCP-T.A
Ferroptosis inducer
|
BCP-T.A is a potent ferroptosis inducer by binding to GPX4 with IC50 of 17 nM in ferroptosis sensitive cell line NCI-H522. |
| PC-22423 |
Erastin
Ferroptosis inducer
|
Erastin is a specific ferroptosis-inducing compound, shows RAS-selective lethality, also targetsvoltage-dependent anion channel 3 (VDAC3). |
| PC-21713 |
GPX4 inhibitor A16
GPX4 inhibitor
|
GPX4 inhibitor A16 (GPX4-IN-9) is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM. |
| PC-20966 |
icFSP1
FSP1 inhibitor
|
icFSP1 is a potent, selective human ferroptosis suppressor protein-1 (hFSP1) inhibitor, promotes ferroptosis and indirectly inhibits FSP1 by inducing condensate formation. |
| PC-20811 |
FSEN1
FSP1 inhibitor
|
FSEN1 (Ferroptosis Sensitizer 1) is a specific small molecule, uncompetitive inhibitor of ferroptosis suppressor protein 1 (FSP1) with IC50 of 133 nM, sensitizes cancer cells to ferroptosis. |
| PC-20810 |
AKI-02
Ferroptosis inhibitor
|
AKI-02 is a hydroxypyridinone-based iron chelator, potently inhibits labile iron-mediated ferroptosis. |
| PC-20267 |
GPX4 inhibitor 24
GPX4 inhibitor
|
GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor, induces ferroptosis in vivo. |
