| Cat. No. |
Product Name |
Information |
| PC-43164 |
Liproxstatin-1
Ferroptosis inhibitor, GPX4 inhibitor
|
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis. |
| PC-61856 |
EPI-743
Ferroptosis inhibitor, Antioxidant
|
EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis. |
| PC-60374 |
FIN56
Ferroptosis inducer
|
FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4. |
| PC-42089 |
RSL3
GPX4 inhibitor
|
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM). |
| PC-42286 |
Piperazine Erastin
Ferroptosis inducer
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
| PC-45261 |
Salinomycin sodium
Ferroptosis inducer
|
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-23010 |
Salinomycin
Ferroptosis inducer
|
Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-22833 |
NCOA4-FTH1 inhibitor 9a
NCOA4-FTH1 inhibitor
|
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. |
| PC-22532 |
SRS 16-86
Ferroptosis inhibitor
|
SRS16-86 is a potent inhibitor of ferroptosis. |
| PC-22475 |
BCP-T.A
Ferroptosis inducer
|
BCP-T.A is a potent ferroptosis inducer by binding to GPX4 with IC50 of 17 nM in ferroptosis sensitive cell line NCI-H522. |
| PC-22423 |
Erastin
Ferroptosis inducer
|
Erastin is a specific ferroptosis-inducing compound, shows RAS-selective lethality, also targetsvoltage-dependent anion channel 3 (VDAC3). |
| PC-21713 |
GPX4 inhibitor A16
GPX4 inhibitor
|
GPX4 inhibitor A16 is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM. |
