| Cat. No. |
Product Name |
Information |
| PC-36116 |
Imidazole ketone erastin
Ferroptosis inducer
|
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. |
| PC-35991 |
SRS11-92
Ferroptosis inhibitor
|
SRS11-92 (SRS 11-92) is a small molecule inhibitor of Ferroptosis and a derivative of Ferrostatin-1 (Fer-1), inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells with EC50 of 6 nM. |
| PC-35744 |
Ferrostatin-1
Ferroptosis inhibitor
|
Ferrostatin-1 (Fer-1) is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM. |
| PC-35743 |
UAMC-3203
Ferroptosis inhibitor
|
UAMC-3203 is a novel potent, drug-like ferroptosis inhibitor with IC50 of 12 nM, inhibit erastin-induced ferroptotic cell death more potently than Ferrostatin-1. |
| PC-43164 |
Liproxstatin-1
Ferroptosis inhibitor, GPX4 inhibitor
|
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis. |
| PC-42855 |
Elesclomol
Cuproptosis inducer
|
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis), specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand, inhibits FDX1-mediated Fe-S cluster biosynthesis. |
| PC-61856 |
EPI-743
Ferroptosis inhibitor, Antioxidant
|
EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis. |
| PC-60374 |
FIN56
Ferroptosis inducer
|
FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4. |
| PC-42089 |
RSL3
GPX4 inhibitor, Ferroptosis inducer
|
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM). |
| PC-42286 |
Piperazine Erastin
Ferroptosis inducer
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
| PC-45261 |
Salinomycin sodium
Ferroptosis inducer
|
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-24932 |
Acevaltrate
Ferroptosis inducer
|
Acevaltrate is a novel ferroptosis inducer and dual inhibitor of PCBP1/2 and GPX4, also inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. |
