| Cat. No. |
Product Name |
Information |
| PC-35744 |
Ferrostatin-1
Ferroptosis inhibitor
|
Ferrostatin-1 (Fer-1) is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM. |
| PC-35743 |
UAMC-3203
Ferroptosis inhibitor
|
UAMC-3203 is a novel potent, drug-like ferroptosis inhibitor with IC50 of 12 nM, inhibit erastin-induced ferroptotic cell death more potently than Ferrostatin-1. |
| PC-43164 |
Liproxstatin-1
Ferroptosis inhibitor, GPX4 inhibitor
|
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis. |
| PC-42855 |
Elesclomol
Cuproptosis inducer
|
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis), specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand, inhibits FDX1-mediated Fe-S cluster biosynthesis. |
| PC-61856 |
EPI-743
Ferroptosis inhibitor, Antioxidant
|
EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis. |
| PC-60374 |
FIN56
Ferroptosis inducer
|
FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4. |
| PC-42089 |
RSL3
GPX4 inhibitor, Ferroptosis inducer
|
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM). |
| PC-42286 |
Piperazine Erastin
Ferroptosis inducer
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
| PC-45261 |
Salinomycin sodium
Ferroptosis inducer
|
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-24567 |
CuATSM
ferroptosis inhibitor, SOD1 modulator
|
CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity. |
| PC-24537 |
DEL-I25
GPX4 R152H activator
|
DEL-I25 is a selective, small molecule activator of GPX4 R152H variant, selectively binds to GPX4 R152H (MST binding KD, 2 uM), restores GPX4R152H enzyme activity, and specifically rescues patient-derived lymphoblast cells. |
| PC-24078 |
Ferfluor-1
Ferroptosis inhibitor
|
Ferfluor-1 is a potent, selective ferroptosis inhibitor, rescues ferroptotic cell death on HT1080 cells with EC50 of 57 nM, also is a specific ferroptosis photoluminescence imaging probe. |
