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Ferrostatin-1

Chemical Structure : Ferrostatin-1

CAS No.: 347174-05-4

Ferrostatin-1 (Ferrostatin 1, Fer-1)

Catalog No.: PC-35744Not For Human Use, Lab Use Only.

Ferrostatin-1 is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM.

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Biological Activity

Ferrostatin-1 (Fer 1) is a potent ferroptosis inhibitor with IC50 of 33 nM, inhibits erastin-induced ferroptosis in HT-1080 cells with EC50 of 60 nM.
Ferrostatin-1 (Fer 1) prevents erastin-induced accumulation of cytosolic and lipid ROS.
Ferrostatin-1 (Fer 1) does not inhibit ERK phosphorylation or arrest the proliferation of HT-1080 cells.

Physicochemical Properties

M.Wt 262.353
Formula C15H22N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

ethyl 3-amino-4-(cyclohexylamino)benzoate

References

1. Devisscher L, et al. J Med Chem. 2018 Oct 25. doi: 10.1021/acs.jmedchem.8b01299.

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