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Elesclomol

Chemical Structure : Elesclomol

CAS No.: 488832-69-5

Elesclomol (STA-4783;STA4783;STA 4783)

Catalog No.: PC-42855Not For Human Use, Lab Use Only.

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Elesclomol (STA-4783) is a small-molecule oxidative stress inducer, exerts selective cytotoxicity by increasing intracellular concentrations of reactive oxygen species (ROS) and induces cell death via mitochondrial apoptosisin cancer cells; selectively kills cisplatin-resistant tumor cells through increased ROS, markedly enhances the therapeutic index of paclitaxel against human tumor xenograft models.

Ovarian Cancer

Phase 2 Clinical

Physicochemical Properties

M.Wt 400.5177
Formula C19H20N4O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 22 mg/mL

Chemical Name/SMILES

Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]

References

1. Berkenblit A, et al. Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):584-90.

2. Kirshner JR, et al. Mol Cancer Ther. 2008 Aug;7(8):2319-27.

3. Wangpaichitr M, et al. Cancers (Basel). 2009;1(1):23-38.

4. Kluza J, et al. Cancer Res. 2012 Oct 1;72(19):5035-47.

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