Catalog No.: PC-36116Not For Human Use, Lab Use Only.
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
Imidazole ketone erastin (IKE, Ferroptosis inducer IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
Imidazole ketone erastin (IKE) potently reduces DLBCL cell number with IC50 of <100 nM (SUDHL6 cell IC50=1 nM).
Imidazole ketone erastin (IKE) exerts antitumor effect by inhibiting system xc-, leading to glutathione depletion (GSH depletion IC50=34 nM, SUDHL6 cells), lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo, induced lipid peroxidation in tumor tissue.
