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Chemical Structure : Liproxstatin-1
CAS No.: 950455-15-9
Catalog No.: PC-43164Not For Human Use, Lab Use Only.
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $248 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
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Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis.
Liproxstatin-1 prevents BODIPY 581/591 C11 oxidation in Gpx4−/− cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis.
Liproxstatin-1 suppresses ferroptosis in Gpx4(-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
| M.Wt | 340.8499 | |
| Formula | C19H21ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine, N-[(3-chlorophenyl)methyl]- |
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1. Friedmann Angeli JP, et al. Nat Cell Biol. 2014 Dec;16(12):1180-91.
2. Kim SE, et la. Nat Nanotechnol. 2016 Nov;11(11):977-985.
3. Zilka O, et al. ACS Cent Sci. 2017 Mar 22;3(3):232-243.
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