EPI-743 (Vatiquinone, ATQ3) |CAS:1213269-98-7 Probechem Biochemicals

Chemical Structure : EPI-743

CAS No.: 1213269-98-7

EPI-743 (Vatiquinone, PTC-743, alpha-tocotrienol quinone, ATQ3)

Catalog No.: PC-61856Not For Human Use, Lab Use Only.

EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis.

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5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$328	In stock
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Biological Activity

EPI-743 (Vatiquinone, ATQ3) prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts with mean EC50 potency values of 17.3-21.8 nM.

EPI-743 (Vatiquinone, ATQ3) is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical response in inherited mitochondrial disease in open label studies.

EPI-743 (Vatiquinone, ATQ3) shows potential for treatment of inherited mitochondrial diseases.

EPI-743 (Vatiquinone, ATQ3) is an analogue of the antioxidant ubidecarenone.

Physicochemical Properties

M.Wt	440.668
Formula	C29H44O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((R,6E,10E)-3-hydroxy-3,7,11,15-tetramethylhexadeca-6,10,14-trien-1-yl)-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione

References

1. Enns GM, et al. Mol Genet Metab. 2012 Jan;105(1):91-102.

2. Martinelli D, et al. Mol Genet Metab. 2012 Nov;107(3):383-8.

3. Sadun AA, et al. Arch Neurol. 2012 Mar;69(3):331-8.

4. Shrader WD, et al. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3693-8.

EPI-743 (Vatiquinone, PTC-743, alpha-tocotrienol quinone, ATQ3)

Biological Activity

Physicochemical Properties

References

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