Catalog No.: PC-45261Not For Human Use, Lab Use Only.
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
Salinomycin sodium inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.
Salinomycin sodium induces ER stress‑mediated autophagy and apoptosis through generation of ROS in human glioma U87MG cells.
Physicochemical Properties
M.Wt
772.9804
Formula
C42H69NaO11
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: ≥ 15 mg/mL
Chemical Name/SMILES
Salinomycin, sodium salt (1:1)
References
1. Mitani M, et al. Antimicrob Agents Chemother. 1976 Apr;9(4):655-60.
2. Lu D, et al. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
3. Yu SN, et al. Oncol Rep. 2017 Jun;37(6):3321-3328.
