Catalog No.: PC-27626Not For Human Use, Lab Use Only.
4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4.
4-Hydroxynonenal (4-HNE) is a lipoperoxidation-derived aldehyde and ALDH2 substrate that promotes oxidative stress, induces ferroptosis, and aggravates myocardial injury, directly evokes myocyte ferroptosis by interacting with GPX4 and deubiquitinase OTUD5 at cysteine residues, leading to increased ubiquitination and degradation of GPX4.
Physicochemical Properties
M.Wt
156.23
Formula
C9H16O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(E)-4-Hydroxynon-2-enal
References
1. Fang H, et al. Nat Commun. 2026 May 21;17(1):8347.
2. Li S, et al. Redox Biol. 2026 Jul 21;96:104314.
3. Martínez-Cortés JE, et al. Pflugers Arch. 2026 Jun 9;478(6):56.
4. Lulu Liu, et al. Adv Sci (Weinh). 2023 Oct;10(28):e2301852.
