| Cat. No. |
Product Name |
Information |
| PC-61856 |
EPI-743
Ferroptosis inhibitor, Antioxidant
|
EPI-743 (Vatiquinone, ATQ3) is an orally bioavailable para-benzoquinone and vitamin-E related compound, shows potent cellular protectant against oxidative stress and aging, inhibits RSL3-induced ferroptosis. |
| PC-60374 |
FIN56
Ferroptosis inducer
|
FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4. |
| PC-42089 |
RSL3
GPX4 inhibitor, Ferroptosis inducer
|
GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM). |
| PC-42286 |
Piperazine Erastin
Ferroptosis inducer
|
Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death.. |
| PC-45261 |
Salinomycin sodium
Ferroptosis inducer
|
Salinomycin sodium is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
| PC-28502 |
NYY-6a
Ferroptosis inhibitor
|
NYY-6a is a potent ferroptosis inhibitor, inhibits RSL3-induced ferroptosis with EC50 of 50 nM in 786-O cell line, functions as a radical trapping antioxidant, alleviates ferroptosis-related acute liver injury in vivo. |
| PC-28420 |
Paeoniflorigenone
TRIM28 modulator, Ferroptosis inducer
|
Paeoniflorigenone (PAG) is a monoterpene compound found in the root of moutan cortex, inhibits the proliferation of tumor cells, directly binds to TRIM28, triggering its phosphorylation at Ser824, induces ferroptosis. |
| PC-26934 |
GPX4 inhibitor C18
GPX4 inhibitor
|
GPX4 inhibitor C18 (GPX4-IN-5) is a covalent inhibitor of glutathione peroxidase 4 (GPX4), shows remarkable inhibitory activity against TNBC cells with IC50 of 10-75 nM. |
| PC-25538 |
Deferoxamine mesylate
Iron chelator, Ferroptosis inhibitor
|
Deferoxamine mesylate (DFOM) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. |
| PC-25537 |
Deferoxamine
Iron chelator, Ferroptosis inhibitor
|
Deferoxamine (DFO) is a small molecule iron chelator and ferroptosis inhibitor, upregulates HIF-1α levels with good antioxidant activity, also shows anti-proliferative activity, can induce apoptosis and autophagy in cancer cells. |
| PC-24932 |
Acevaltrate
Ferroptosis inducer
|
Acevaltrate is a novel ferroptosis inducer and dual inhibitor of PCBP1/2 and GPX4, also inhibits the Na+/K+-ATPase activity in the rat kidney and brain hemispheres with IC50s of 22.8 μM and 42.3 μM, respectively. |
| PC-23010 |
Salinomycin
Ferroptosis inducer
|
Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells. |
