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PKUMDL-LC-102

Chemical Structure : PKUMDL-LC-102

CAS No.: 22431-06-7

PKUMDL-LC-102

Catalog No.: PC-24821Not For Human Use, Lab Use Only.

PKUMDL-LC-102 is a selective, allosteric small molecule GPX4 activator (150% activation at 39.2 μM), shows no activity against COX-1, COX-2, mPGES-1, 5-LOX, LTA4H, 12-LOX, and 15-LOX.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PKUMDL-LC-102 is a selective, allosteric small molecule GPX4 activator (150% activation at 39.2 μM), shows no activity against COX-1, COX-2, mPGES-1, 5-LOX, LTA4H, 12-LOX, and 15-LOX.

Physicochemical Properties

M.Wt 219.20
Formula C10H9N3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-amino-3a,8a-dihydroxy-3a,8a-dihydroindeno[1,2-d]imidazol-8(3H)-one

References

1. Li C, et al. Front Pharmacol. 2018 Oct 3:9:1120.

2. Liu X, et al. J Orthop Translat. 2025 May 7;52:344-359.

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