Catalog No.: PC-24567Not For Human Use, Lab Use Only.
CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity.
CuATSM is orally available brain-penetrant copper compound that scavenges free radicals, inhibits lipid peroxidation and ferroptosis, stabilises various ALS-associated variants of the SOD1 protein, reducing misfolding and toxicity. CuATSM potently inhibits ferroptosis, prevented SMC phenotypic switch, neointimal formation and arterial inflammation in mice. CuATSM protects against a broad variety of SOD1 mutations in cell culture model of SOD1-fALS CuATSM improves motor function and extends survival but is not tolerated at a high dose in SOD1G93A mice with a C57BL/6 background CuATSM has repeatedly shown in mouse models to be a promising therapeutic treatment for SOD1-associated ALS and is currently in Phase II/III clinical trials for the treatment of ALS.
