Catalog No.: PC-22833Not For Human Use, Lab Use Only.
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells.
NCOA4-FTH1 inhibitor 9a is a new ferroptosis inhibitor through disrupting the NCOA4-FTH1 protein-protein interaction, reduces intracellular ferrous iron, inhibits Erastin-induced ferroptosiswith EC50 of 0.29 μM in HT22 cells. NCOA4-FTH1 inhibitor 9a directly binds to recombinant protein NCOA4383–522 (Kd=7.48 uM) and effectively blocks the NCOA4383–522–FTH1 interaction. NCOA4-FTH1 inhibitor 9a significantly ameliorates the ischemic-refusion injury in rat model of ischemic stroke. NCOA4-FTH1 inhibitor 9a is a selective ferroptosis inhibitor that effectively suppresses lipid peroxidation and rescues cells from ferroptosis. NCOA4-FTH1 inhibitor 9a inhibits lysosomal ferritin degradation and localizes in autophagosomes. effectively blocks RSL3-induced ferroptosis in HT22 cells (EC50 = 3.66 μM).
