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Ferfluor-1

Chemical Structure : Ferfluor-1

CAS No.: 3030473-59-4

Ferfluor-1

Catalog No.: PC-24078Not For Human Use, Lab Use Only.

Ferfluor-1 is a potent, selective ferroptosis inhibitor, rescues ferroptotic cell death on HT1080 cells with EC50 of 57 nM, also is a specific ferroptosis photoluminescence imaging probe.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Ferfluor-1 is a potent, selective ferroptosis inhibitor, rescues ferroptotic cell death on HT1080 cells with EC50 of 57 nM, also is a specific ferroptosis photoluminescence imaging probe.
Ferfluor-1 exhibits improved in vitro/in vivo absorption, distribution, metabolism, and elimination (ADME) characteristics and optimal BBB permeability comnpare with Fer-1.
Ferfluor-1 shows potent anti-ferroptosis with EC50 values of 57, 75, 2.3 nM in HT1080, OS-RC-2 and SH-SY5Y cells, respectively.
Ferfluor-1 exhibits authentic behavior like Fer-1 as being a specific ferroptosis inhibitor.
Ferfluor-1 exhibits a maximum absorption peak at 350 nm and a fluorescent (FL) emission peak at 525 nm with a large Stokes shift of 175 nm in phosphate-buffered saline (PBS) (with 0.5% DMSO, 37 ℃, pH =7.4).
Ferfluor-1 is a specific ferroptosis probe has been explored in both living cells and in vivo zebrafish.
Ferfluor-1 is a potential tool for ferroptosis-related diagnostic and therapeutic applications in the central nervous system.

Physicochemical Properties

M.Wt 288.41
Formula C15H20N4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N1-cyclohexyl-4-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1,2-diamine

References

1. Yan J, et al. Angew Chem Int Ed Engl. 2025 Feb 21:e202502195.

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