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FerroLOXIN-2

Chemical Structure : FerroLOXIN-2

CAS No.: 2773428-34-3

FerroLOXIN-2

Catalog No.: PC-20924Not For Human Use, Lab Use Only.

FerroLOXIN-2 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

FerroLOXIN-2 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo.

Physicochemical Properties

M.Wt 490.30
Formula C23H16BrF4N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

FC1=CC(N2C=C(C3=CC=CC=C3)N=C2NCC4=CC=C(C(F)(F)F)C(Br)=C4)=CC=C1

References

1. Haider H Dar, et al. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2218896120.

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