Salinomycin | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : Salinomycin

CAS No.: 53003-10-4

Salinomycin (Procoxacin)

Catalog No.: PC-23010Not For Human Use, Lab Use Only.

Packing	Price	Stock
10 mg	$98	In stock
25 mg	$158	In stock
50 mg	$258	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
Salinomycin sodium inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.
Salinomycin sodium induces ER stress‑mediated autophagy and apoptosis through generation of ROS in human glioma U87MG cells.

Physicochemical Properties

M.Wt	751.01
Formula	C42H70O11
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

References

1. Mitani M, et al. Antimicrob Agents Chemother. 1976 Apr;9(4):655-60.

2. Lu D, et al. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.

3. Yu SN, et al. Oncol Rep. 2017 Jun;37(6):3321-3328.

Salinomycin (Procoxacin)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.