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Chemical Structure : Salinomycin
CAS No.: 53003-10-4
Catalog No.: PC-23010Not For Human Use, Lab Use Only.
Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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Salinomycin is a polyether ionophore antibacterial agent that shows effects on mitochondrial ion translocation and respiration, inhibits Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation and induces ferroptosis in cancer cells.
Salinomycin sodium inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.
Salinomycin sodium induces ER stress‑mediated autophagy and apoptosis through generation of ROS in human glioma U87MG cells.
| M.Wt | 751.01 | |
| Formula | C42H70O11 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid |
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1. Mitani M, et al. Antimicrob Agents Chemother. 1976 Apr;9(4):655-60.
2. Lu D, et al. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
3. Yu SN, et al. Oncol Rep. 2017 Jun;37(6):3321-3328.
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