LOC1886 | GPX4 inhibitor | Probechem Biochemicals

Chemical Structure : LOC1886

LOC1886 (LOC-1886)

Catalog No.: PC-49542Not For Human Use, Lab Use Only.

LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.

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Biological Activity

LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.

Physicochemical Properties

M.Wt	241.250
Formula	C13H11N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1H-imidazol-1-yl)(4-methoxy-1H-indol-2-yl)methanone

References

1. Liu H, et al. Cell Chem Biol. 2022 Dec 15;29(12):1680-1693.e9.

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LOC1886 (LOC-1886)

Biological Activity

Physicochemical Properties

References

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