Ironomycin | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : Ironomycin

Ironomycin (Ironomycin AM5)

Catalog No.: PC-72335Not For Human Use, Lab Use Only.

Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism.

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Biological Activity

Ironomycin (Ironomycin AM5) is a lysosomal iron-targeting small molecule that reduces the mitochondrial iron load, resulting in the potent disruption of mitochondrial metabolism, induces ferroptosis in cancer cells.
Ironomycin promotes the recruitment and activation of BAX/BAK, but the resulting mitochondrial outer membrane permeabilization (MOMP) does not lead to potent activation of the apoptotic caspases, nor is the ensuing cell death prevented by inhibiting the previously established pathways of programmed cell death.
Ironomycin exhibits marked in vitro and in vivo synergy with venetoclax and overcomes venetoclax resistance in primary patient samples.
Ironomycin AM5 exhibits a more potent and selective activity against breast cancer stem cells (CSCs) in vitro and in vivo, by accumulating and sequestering iron in lysosomes.

Physicochemical Properties

M.Wt	709
Formula	C45H73NO10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility
Chemical Name/SMILES	(2R)-2-[(2R,5S,6R)-6-{(2S,3S,4S,6R)-6-[(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-2,10,12-trimethyl-15-(2-propyn-1-ylamino)-1,6,8-trioxadispiro[4.1.5.3 ]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxo-2-octanyl}-5-methyltetrahydro-2H-pyran-2-yl]butanoic acid

References

1. Garciaz S, et al. Cancer Discov. 2021 Dec 3. doi: 10.1158/2159-8290.CD-21-0522.

2. Devin J, et al. Cancer Res. 2022 Jan 25:canres.0218.2021.

3. Versini A, et al. Chemistry. 2020 Jun 10;26(33):7416-7424.

4. Mai TT, et al. Nat Chem. 2017 Oct;9(10):1025-1033.

Ironomycin (Ironomycin AM5)

Biological Activity

Physicochemical Properties

References

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