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Chemical Structure : YL-939
CAS No.: 3023925-68-7
Catalog No.: PC-49555Not For Human Use, Lab Use Only.
YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays.
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|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $658 | In stock | |
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| 100 mg | Get quote |
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YL-939 is a novel non-classical and specific ferroptosis inhibitor, targets and binds directly to the prohibitin 2 (PHB2) protein with Kd of 3.43 uM in SPR assays.
YL-939 is not an inhibitor of apoptosis, necroptosis, pyroptosis, and cuprotosis. did not show impact on the currently known signal pathways regulating ferroptosis.
YL-939 specifically protected cells from ferroptosis in erastin-induced ferroptosis models (HT1080 and ES-2) with EC50 of 0.14 and 0.09 uM, repectively.
YL-939 protected PHB2 from the degradation by pronase, but had no effect on the PHB2 isoform PHB1, as well as VDAC1 and VDAC2.
YL-939 treatment dose-dependently up-regulated ferritin protein and the mRNA expression of FTH1 and FTL, similar to the effect of PHB2 knockdown, also dose-dependently reduced the intracellular iron level elevated by erastin treatment, blocked autophagosomes/lysosomes, and hence inhibited ferritinophagy.
YL-939 (3 mg/kg) ameliorated liver damage in an acetaminophen (APAP)-induced acute liver injury model.
| M.Wt | 426.524 | |
| Formula | C25H26N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine |
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1. Wei Yang, et al. Nat Commun. 2022 Dec 3;13(1):7473.
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