BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
BAY-524 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function.
BAY-524 impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
BAY-524 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.
