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Chemical Structure : BAY-524
Catalog No.: PC-35362Not For Human Use, Lab Use Only.
BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
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BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
BAY-524 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function.
BAY-524 impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
BAY-524 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.
| M.Wt | 482.492 | |
| Formula | C24H24F2N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Baron AP, et al. Elife. 2016 Feb 17;5. pii: e12187.
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