You are here:Home-Chemical Inhibitors & Agonists-Cell Cycle/DNA Damage-Checkpoint Kinase (Chk)

Request The Product List ofCheckpoint Kinase (Chk) Checkpoint Kinase (Chk)

Cat. No. Product Name Information
PC-49284

BML-277

Chk2 inhibitor

BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases.
PC-35602

PF-00477736

PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM).
PC-63043

SAR-020106

SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).
PC-62476

MK 8776

MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties.
PC-62037

MARPIN

MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM.
PC-60583

MU 380

A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2.
PC-60311

SAR-020106

A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM.
PC-60291

Debromohymenialdisine

A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively.
PC-60290

SB-218078

A potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
PC-60286

PD-321852

A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
PC-60284

PV-1115

A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM.
PC-60283

PV-1019

A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com