Cat. No. |
Product Name |
Information |
PC-49284 |
BML-277
Chk2 inhibitor
|
BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases. |
PC-35602 |
PF-00477736
|
PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM). |
PC-63043 |
SAR-020106
|
SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM). |
PC-62476 |
MK 8776
|
MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties. |
PC-62037 |
MARPIN
|
MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM. |
PC-60583 |
MU 380
|
A novel potent, selective CHK1 inhibitor 2 nM, >80-fold selectivity over CHK2. |
PC-60311 |
SAR-020106
|
A potent, selective, ATP-competitive Chk1 inhibitor with IC50 of 13.3 nM. |
PC-60291 |
Debromohymenialdisine
|
A marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively. |
PC-60290 |
SB-218078
|
A potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM. |
PC-60286 |
PD-321852
|
A potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM. |
PC-60284 |
PV-1115
|
A potent and highly selective Chk2 inhibitor with IC50 of 0.14 nM. |
PC-60283 |
PV-1019
|
A potent, ATP-competitive and highly selective Chk2 inhibitor with IC50 of 138 nM. |