Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NSC109555 ditosylate
Catalog No.: PC-60282Not For Human Use, Lab Use Only.
NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NSC109555 ditosylate (DDUG) is a potent, selective, reversible, ATP-competitive Chk2 inhibitor with IC50 of 0.2 uM.
NSC109555 displays no effect on a range of other kinases including Chk1 (IC50>10 uM).
NSC109555 inhibits histone H1 phosphorylation (IC50=0.24 uM) and attenuates mitochondrial ATP synthesis.
NSC109555 exhibits antiproliferative activity in a number of leukemias in vivo.
| M.Wt | 752.86 | |
| Formula | C19H24N10O.2C7H8O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Jobson AG, et al. Mol Pharmacol. 2007 Oct; 72(4):876-84.
2. Gogineni VR, et al. Cancer Lett. 2011 Dec 26;313(1):64-75.
3. Mikles-Robertson F, et al. Cancer Res. 1980 Apr;40(4):1054-61.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
