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Chemical Structure : GDC-0575
CAS No.: 1196541-47-5
Catalog No.: PC-60276Not For Human Use, Lab Use Only.
GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $558 | In stock | |
| 200 mg | $758 | In stock | |
| 1 g | $758 | In stock |
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GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
GDC-0575 (ARRY-575, RG-7741) enhances the killing of primary AML cells ex vivo by inducing apoptosis combined with AraC, blocks the activation of CHK1 induced by AraC via decrease in the level of Tyr15-phosphorylated CDK2 at 100 nM in AML cells.
| M.Wt | 377.286 | |
| Formula | C17H21BrN4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-indol-3-yl)cyclopropanecarboxamide |
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1. Duan W, et al. Front Oncol. 2014 Dec 19;4:368.
2. Di Tullio A, et al. Nat Commun. 2017 Nov 22;8(1):1679.
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