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Chemical Structure : VER-158411
Catalog No.: PC-60279Not For Human Use, Lab Use Only.
VER-158411 (V-158411) is a potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.
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VER-158411 (V-158411) is a potent, selective, ATP-competitive Chk1 and Chk2 inhibitor with IC50 of 4.4 nM and 4.5 nM, respectively.
VER-158411 dispalys >1,000-fold selectivity over CDK1.
VER-158411 reduces pChk1 (S296) and pChk2 (S516) levels in a concentration dependent fashion in cells treated with etoposide with IC50s of 48 nM for Chk1 and 904 nM for Chk2.
VER-158411 potentiates the cytotoxicity of chemotherapeutic agents in a variety of p53 deficient human tumor cell lines (GI50=0.5-9.5 uM) and human colon tumor xenograft models.
| M.Wt | 538.652 | |
| Formula | C31H34N6O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Massey AJ, et al. Oncotarget. 2015 Nov 3;6(34):35797-812.
2. Alsubhi N, et al. Mol Oncol. 2016 Feb;10(2):213-23.
3. Wayne J, et al. Oncotarget. 2016 Dec 20;7(51):85033-85048.
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