Chemical Structure : SB218078
CAS No.:
135897-06-2
SB218078
(SB-218078, SB 218078)
Catalog No. : PC-60290Not For Human Use, Lab Use Only.
SB218078 (SB-218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6029001
Biological Activity
SB218078 (SB-218078) is a potent inhibitor of Chk1 that blocks phosphorylation of cdc25 with IC50 of 15 nM.
Physicochemical Properties
M.Wt
393.4
Formula
C24H15N3O3
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5,6,7,8-tetrahydro-13H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-13,15(14H)-dione
References
1. Jackson JR, et al. Cancer Res.
2. Fishler T, et al. Oncogene.
3. Akasaka T, et al. Int J Oncol
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