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Chemical Structure : PD-321852
Catalog No.: PC-60286Not For Human Use, Lab Use Only.
PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
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PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
PD-321852 potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines.
PD-321852 inhibits gemcitabine-induced Rad51 focus formation, and depletes RAD51 proteins in pancreatic cancer cells.
| M.Wt | 468.33 | |
| Formula | C24H19Cl2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Parsels LA, et al. Mol Cancer Ther. 2009 Jan;8(1):45-54.
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