PD-321852 |CAS: 622856-21-7 Probechem Biochemicals

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Chemical Structure : PD-321852

PD-321852 (PD 321852;PD321852)

Catalog No.: PC-60286Not For Human Use, Lab Use Only.

PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PD-321852 is a potent, reasonably selective Chk1 inhibitor with cell IC50 of 5 nM.
PD-321852 potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines.
PD-321852 inhibits gemcitabine-induced Rad51 focus formation, and depletes RAD51 proteins in pancreatic cancer cells.

Physicochemical Properties

M.Wt	468.33
Formula	C24H19Cl2N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

References

1. Parsels LA, et al. Mol Cancer Ther. 2009 Jan;8(1):45-54.

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PD-321852 (PD 321852;PD321852)

Biological Activity

Physicochemical Properties

References

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