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Chemical Structure : XL-844
Catalog No.: PC-60285Not For Human Use, Lab Use Only.
XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
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XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
XL-844 increases gemcitabine-induced H2AX phosphorylation, blocks Cdc25A phosphorylation, and induces premature mitotic entry.
XL-844 significantly enhances gemcitabine antitumor activity in a PANC-1 xenograft model.
| M.Wt | 287.323 | |
| Formula | C14H17N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Riesterer O, et al. Invest New Drugs. 2011 Jun;29(3):514-22.
2. Matthews DJ, et al. Cell Cycle. 2007 Jan 1;6(1):104-10.
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