| Cat. No. |
Product Name |
Information |
| PC-23369 |
BBI-2779
CHK1 inhibitor
|
BBI-2779 is a potent, selective and orally bioavailable inhibitor of CHK1 with biochemical IC50 of 0.5 nM and cellular IC50 of 3 nM (pCHK1-S345 activity in HT29 cells), 160-fold selective for CHK1 over CHK2. |
| PC-49284 |
BML-277
Chk2 inhibitor
|
BML-277 (BML277) is a potent, selective and ATP-competitive inhibitor of Chk2 serine/threonine kinase with IC50 of 15 nM, >1000-fold selectivity over Chk1 and Cdk1/B kinases. |
| PC-35602 |
PF-00477736
CHK1 inhibitor
|
PF-00477736 (PF-477736) is a potent, selective, ATP-competitive inhibitor of Chk1 with Ki of 0.49 nM, also inhibits Chk2 (Ki=47 nM) and poorly inhibits CDK1 activity (Ki=9.9 uM). |
| PC-35362 |
BAY-524
BUB1 inhibitor
|
BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM. |
| PC-43443 |
CHIR-124
CHK1 inhibitor
|
CHIR-124 is a potent, selective Chk1 inhibitor with in vitro IC50 of 0.3 nM, 2,000-fold selectivity over Chk2. |
| PC-63128 |
BAY-1816032
BUB1 inhibitor
|
BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases. |
| PC-63043 |
SAR-020106
CHK1 inhibitor
|
SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM). |
| PC-62476 |
MK 8776
CHK1 inhibitor
|
MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties. |
| PC-62037 |
MARPIN
CHK1 inhibitor
|
MARPIN is a novel ATR-Chk1 pathway inhibitor that inhibits hydroxyurea (HU)-induced phosphorylation of Ser345 on Chk1 with IC50 of 7.7 uM. |
| PC-60583 |
MU 380
CHK1 inhibitor
|
MU 380 is a novel potent, selective CHK1 inhibitor with IC50 of 2 nM, >80-fold selectivity over CHK2. |
| PC-60310 |
GNE-900
CHK1 inhibitor
|
GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM. |
| PC-60291 |
Debromohymenialdisine
Chk1/Chk2 inhibitor
|
Debromohymenialdisine (SKF108753) is a marine sponge alkaloid that inhibits Chk1 and Chk2 with IC50 of 3 and 3.5 uM, respectively. |
