BBI-355 | CHK1 inhibitor | Probechem Biochemicals

Chemical Structure : BBI-355

BBI-355 (BBI 355, BBI355)

Catalog No.: PC-27305Not For Human Use, Lab Use Only.

BBI-355 is a potent, selective, and orally available Checkpoint kinase 1 (CHK1) inhibitor with IC50 of 0.6 nM, shows >150-fold selectivity over CHK2, demonstrates strong antitumor activity.

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Biological Activity

BBI-355 is a potent, selective, and orally available Checkpoint kinase 1 (CHK1) inhibitor with IC50 of 0.6 nM, shows >150-fold selectivity over CHK2, demonstrates strong antitumor activity.

Physicochemical Properties

M.Wt	406.45
Formula	C20H22N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-(4-(((1R,3S)-3-aminocyclopentyl)oxy)-2-methoxy-6-methylpyridin-3-yl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile

References

1. Meyer ST, et al. J Med Chem. 2026 Jul 15. doi: 10.1021/acs.jmedchem.6c00822.

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BBI-355 (BBI 355, BBI355)

Biological Activity

Physicochemical Properties

References

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