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Chemical Structure : SAR-020106
CAS No.: 1184843-57-9
Catalog No.: PC-63043Not For Human Use, Lab Use Only.
SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).
SAR-020106 inhibits HT29 cells with IC50 of 0.53 uM in SRB cytotoxicity assay.
SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.
| M.Wt | 382.852 | |
| Formula | C19H19ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile |
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1. Reader JC, et al. J Med Chem. 2011 Dec 22;54(24):8328-42.
2. Walton MI, et al. Mol Cancer Ther. 2010 Jan;9(1):89-100.
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