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Chemical Structure : 2OH-BNPP1
CAS No.: 833481-73-5
Catalog No.: PC-21172Not For Human Use, Lab Use Only.
2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.
2OH-BNPP1 dose-dependently impaired the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines.
2OH-BNPP1 abrogates SMAD2 phosphorylation in vivo.
| M.Wt | 297.36 | |
| Formula | C16H19N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[[4-Amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]phenol |
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1. Nyati S, et al. Sci Signal. 2015 Jan 6;8(358):ra1.
2. Jiang N, et al. J Exp Clin Cancer Res. 2021 Dec 1;40(1):378.
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