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2OH-BNPP1

Chemical Structure : 2OH-BNPP1

CAS No.: 833481-73-5

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2OH-BNPP1

Catalog No.: PC-21172Not For Human Use, Lab Use Only.

2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.

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Biological Activity

2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.
2OH-BNPP1 dose-dependently impaired the TGFβ-induced phosphorylation of proteins that mediate canonical and non-canonical TGFβ signaling in multiple cancer cell lines.
2OH-BNPP1 abrogates SMAD2 phosphorylation in vivo.

Physicochemical Properties

M.Wt 297.36
Formula C16H19N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[4-Amino-1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl]methyl]phenol

References

1. Nyati S, et al. Sci Signal. 2015 Jan 6;8(358):ra1.

2. Jiang N, et al. J Exp Clin Cancer Res. 2021 Dec 1;40(1):378.

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