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Cat. No. Product Name Information
PC-35362

BAY-524

BUB1 inhibitor

BAY-524 (BAY524) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 450 nM.
PC-43443

CHIR-124

CHK1 inhibitor

CHIR-124 is a potent, selective Chk1 inhibitor with in vitro IC50 of 0.3 nM, 2,000-fold selectivity over Chk2.
PC-63128

BAY-1816032

BUB1 inhibitor

BAY-1816032 (BAY1816032) is a highly potent, selective, orally active BUB1 mitotic checkpoint serine/threonine kinase with IC50 of 7 nM, displays excellent selectivity on a panel of 395 kinases.
PC-60310

GNE-900

GNE-900 (GNE900) is a potent, selective, ATP-competitive, and orally bioavailable Chk1 inhibitor with IC50 of <1 nM.
PC-60285

XL-844

XL-844 (EXEL9844) is a potent, specific, orally available, ATP‑competitive inhibitor of Chk1 and Chk2 with Ki of 2.2 nM and 0.07 nM, respectively.
PC-60276

GDC-0575

Chk1 inhibitor

GDC-0575 (ARRY-575, RG-7741) is a potent, selective and orally bioavailable Chk1 inhibitor with IC50 of 1.2 nM.
PC-45427

Prexasertib

CHK1 inhibitor

Prexasertib (LY-2606368) is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
PC-44037

LY2603618

CHK1 inhibitor

Rabusertib (LY2603618) is a potent and selective small molecule inhibitor of Chk1 (IC50= 7 nM).
PC-42769

AZD-7762

AZD-7762 (AZD7762) is a potent and selective inhibitor of Chk1/2 with IC50 of 5 nM.
PC-45429

CCT-244747

CHK1 inhibitor

CCT-244747 (CCT244747) is a potent, highly selective, orally active, ATP competitive CHK1 inhibitor with biochemical IC50 of 8 nM.
PC-45574

CCT-245737

CHK1 inhibitor

CCT-245737 (SRA-737) is a highly potent, selective, ATP-competitive inhibitor of Chk1 with IC50 of 1.3 nM.
PC-21172

2OH-BNPP1

BUB1 inhibitor

2OH-BNPP1 is a small molecule inhibitor of BUB1 (budding uninhibited by benzimidazoles-1) kinase, abrogates TGFβ signaling.

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