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Chemical Structure : Prexasertib dihydrochloride
CAS No.: 1234015-54-3
Catalog No.: PC-45428Not For Human Use, Lab Use Only.
Prexasertib (LY-2606368) dihydrochloride is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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Prexasertib (LY-2606368) dihydrochloride is a potent, selective, ATP-competitive inhibitor of CHK1 with Ki of 0.9 nM.
Prexasertib (LY-2606368) potently abrogates the G2-M checkpoint activated by doxorubicin in p53-deficient HeLa cells with EC50 of 9 nM.
Prexasertib (LY-2606368) causes replication catastrophe in vitro and in vivo.
Prexasertib (LY-2606368) shows significant tumor growth inhibition in xenograft tumor models.
| M.Wt | 438.311 | |
| Formula | C18H21Cl2N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 32 mg/mL |
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| Chemical Name/SMILES |
2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-, hydrochloride (1:2) |
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1. King C, et al. Mol Cancer Ther. 2015 Sep;14(9):2004-13.
2. Lowery CD, et al. Clin Cancer Res. 2017 Aug 1;23(15):4354-4363.
3. Sen T, et al. Cancer Res. 2017 Jul 15;77(14):3870-3884.
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