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GDC-0425

Chemical Structure : GDC-0425

CAS No.: 1200129-48-1

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GDC-0425 (RG-7602;RG7602;GDC0425)

Catalog No.: PC-60278Not For Human Use, Lab Use Only.

GDC-0425 (RG7602) is a potent, selective and orally active Chk1 inhibitor.

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10 mg $98 In stock
25 mg $148 In stock
50 mg $248 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GDC-0425 (RG7602) is a potent, selective and orally active Chk1 inhibitor.
GDC-0425 (RG7602) enhances gemcitabine efficacy in tumor xenograft models.
GDC-0425 (RG7602) shows greater chemopotentiation in cancer cell lines lacking p53 activity.

Physicochemical Properties

M.Wt 321.384
Formula C18H19N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile

References

1. Takahashi RH, et al. Drug Metab Dispos. 2017 May;45(5):430-440.

2. Infante JR, et al. Clin Cancer Res. 2017 May 15;23(10):2423-2432.

3. Lee HJ, et al. Mol Cancer Ther. 2017 Apr;16(4):694-704.

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