Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
    English |     Chinese

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Antibiotics and Antivirals-Fungal-ISFP10
ISFP10

Chemical Structure : ISFP10

CAS No.: 2455482-40-1

Add to Favorites

ISFP10

Catalog No.: PC-23892Not For Human Use, Lab Use Only.

ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ISFP10 is a specific small molecule inhibitor of A. fumigatus phosphoglucomutase (AfPGM) with IC50 of 2 uM, 50-fold selectivity over the human PGM enzyme.
ISFP10 inhibits AfPGMC353 with IC50 of 4 uM, 50- and 25-fold higher IC50 values for HsPGM.
ISFP10 can also significantly reduce Pmpgm2 activity in vitro.
ISFP10 displays antifungal activity in a concentration-dependent manner against C. albicans and C. glabrata.

Physicochemical Properties

M.Wt 311.36
Formula C17H13NO3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

benzyl 4-(3-oxoisothiazol-2(3H)-yl)benzoate

References

1. Yan K, et al. J Biol Chem. 2022 Jun;298(6):102003.

2. Kottom TJ, et al. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0075623.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: