Chemical Structure : Tps1 inhibitor 4456dh
CAS No.:
Tps1 inhibitor 4456dh
(4456-dichloride hydrate)
Catalog No.: PC-24646Not For Human Use, Lab Use Only.
Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Tps1 inhibitor 4456dh is a small molecule inhibitor of the fungal first enzyme in the trehalose biosynthesis pathway, trehalose-6-phosphate synthase (Tps1), demonstrates broad-spectrum inhibitory effects against multiple pathogenic fungal species, including Candida and Cryptococcus.
4456dh displays temperature-dependent fungicidal activity, phenocopying the tps1Δ fungicidal phenotype.
4456dh inhibits the biosynthesis of trehalose in fungal cells.
4456dh shows binding affinities with recombinant 6xHis-CaTps1 (C. albicans Tps1) and 6xHis-CnTps1 (C. neoformans Tps1) are 7.1 μM and 33.4 μM, respectively.
4456dh renders normally thermotolerant fungal pathogens unable to survive at elevated temperatures.
Physicochemical Properties
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M.Wt
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390.28
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Formula
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C14H17Cl2N5O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(1-methyl-1H-pyrazol-4-yl)thiazol-2-yl)-2-(pyridin-2-yl)acetamide dihydrochloride hydrate
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References
1. Miao Y, et al. bioRxiv [Preprint]. 2025 Mar 7:2025.03.07.642065.
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