Catalog No.: PC-25620Not For Human Use, Lab Use Only.
Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL.
Isoxazole 1 is a potent, specific inhibitor of C. neoformans acetyl-CoA synthetase (CnAcs1) with IC50 of 8.6 uM, shows antifungal activity against WT C. neoformans strain H99 with MIC of 2 ug/mL.
Isoxazole 1 inhibits the growth of H99 with a MIC of 32 ug/mL.
shows no antifungal activity against C. albicans or C. glabrata, two Candida spp. which lack Acl enzymes.
Isoxazole 1 is synergistic with fluconazole in vitro, with a Fractional Inhibitory Concentration Index (FICI) of 0.5.
Isoxazole 1 is also synergistic with rapamycin against C. neoformans (FICI = 0.5).
Isoxazole 1 does not inhibit Saccharomyces cerevisiae Acs1 (ScAcs1), Candida albicans Acs2 (CaAcs2), Aspergillus fumigatus Acs1 (AfAcs1), Coccidioides immitis Acs1 (CiAcs1), and Cryptococcus neoformans Acs1 (CnAcs1), and human acetyl-CoA synthetase ACSS2.
