Catalog No.: PC-22712Not For Human Use, Lab Use Only.
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
MBX-7591 exhibits synergy with triazole antifungal drugs and activity against pan-azole-resistant A. fumigatus isolates.
MBX-7591 has additional potent activity against Rhizopus species and CO2-dependent activity against Cryptococcus neoformans.
MBX-7591 increases cell membrane saturation by decreasing oleic acid content.
MBX-7591 has low toxicity in vivo and shows good efficacy in decreasing fungal burden in a murine model of invasive pulmonary aspergillosis.
