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Chemical Structure : MBX-7591
Catalog No.: PC-22712Not For Human Use, Lab Use Only.
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
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MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
MBX-7591 exhibits synergy with triazole antifungal drugs and activity against pan-azole-resistant A. fumigatus isolates.
MBX-7591 has additional potent activity against Rhizopus species and CO2-dependent activity against Cryptococcus neoformans.
MBX-7591 increases cell membrane saturation by decreasing oleic acid content.
MBX-7591 has low toxicity in vivo and shows good efficacy in decreasing fungal burden in a murine model of invasive pulmonary aspergillosis.
| M.Wt | 392.52 | |
| Formula | C23H24N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gutierrez-Perez C, et al. mBio. 2024 Jul 17;15(7):e0116624.
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