Chemical Structure : MBX-7591
CAS No.:
2096324-50-2
MBX-7591
(MBX7591)
Catalog No.: PC-22712Not For Human Use, Lab Use Only.
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
MBX-7591 is a nonspirocyclic piperidine antifungal agent with MIC of 1.2 uM for A. fumigatus, shows promising antifungal activity against Aspergillus fumigatus and other pathogenic fungi, including strains resistant to triazoles.
MBX-7591 exhibits synergy with triazole antifungal drugs and activity against pan-azole-resistant A. fumigatus isolates.
MBX-7591 has additional potent activity against Rhizopus species and CO2-dependent activity against Cryptococcus neoformans.
MBX-7591 increases cell membrane saturation by decreasing oleic acid content.
MBX-7591 has low toxicity in vivo and shows good efficacy in decreasing fungal burden in a murine model of invasive pulmonary aspergillosis.
Physicochemical Properties
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M.Wt
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392.52
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Formula
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C23H24N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(4-(4-((pyridin-4-yloxy)methyl)benzyl)piperidin-1-yl)(thiophen-3-yl)methanone
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References
1. Gutierrez-Perez C, et al. mBio. 2024 Jul 17;15(7):e0116624.
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