Catalog No.: PC-21852Not For Human Use, Lab Use Only.
NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.
NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.
Met496 of Gln4 is a critical residue for NP-BTA's species-selective target engagement and potency.
NP-BTA demonstrates efficacy against diverse C. albicans strains.
NP-BTA potently inhibits Gln4 enzyme-catalyzed aminoacylation of synthetic tRNAGln with IC50 of 108 nM.
NP-BTA does not inhibit translation in mammalian cells.
NP-BTA displays therapeutic potential in C. elegans candidiasis and mouse dermatomycosis models.
NP-BTA potently inhibits tRNA amino-acylation by fungal Gln4 through an allosteric mechanism that is unique amongst all other reported tRNA synthetase inhibitors.
Physicochemical Properties
M.Wt
231.27
Formula
C11H9N3OS
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-pyrimidinyl-β-thiophenylacrylamide
References
1. Puumala E, et al. Cell Chem Biol. 2024 Feb 20:S2451-9456(24)00046-1.
