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Chemical Structure : NP-BTA
CAS No.: 544420-99-7
Catalog No.: PC-21852Not For Human Use, Lab Use Only.
NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.
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|---|---|---|---|
| 10 mg | $248 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
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NP-BTA is a potent, allosteric inhibitor of C. albicans glutaminyl-tRNA synthetase Gln4 with ITC KD of 180 nM and IC50 of 108 nM, strongly inhibits Candida albicans growth.
Met496 of Gln4 is a critical residue for NP-BTA's species-selective target engagement and potency.
NP-BTA demonstrates efficacy against diverse C. albicans strains.
NP-BTA potently inhibits Gln4 enzyme-catalyzed aminoacylation of synthetic tRNAGln with IC50 of 108 nM.
NP-BTA does not inhibit translation in mammalian cells.
NP-BTA displays therapeutic potential in C. elegans candidiasis and mouse dermatomycosis models.
NP-BTA potently inhibits tRNA amino-acylation by fungal Gln4 through an allosteric mechanism that is unique amongst all other reported tRNA synthetase inhibitors.
| M.Wt | 231.27 | |
| Formula | C11H9N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-pyrimidinyl-β-thiophenylacrylamide |
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1. Puumala E, et al. Cell Chem Biol. 2024 Feb 20:S2451-9456(24)00046-1.
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