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Cat. No. Product Name CAS No. Information
PC-45580

Caficrestat

1355612-71-3 AT-001 (Caficrestat) is a highly potent, selective inhibitor of aldose reductase enzymatic activity with IC50 of 28.9 pM.
PC-38679

Govorestat

2170729-29-8 Govorestat (AT-007) is a potent, selective, CNS-penetrant aldose reductase (aldehyde reductase) inhibitor with IC50 of 0.1 nM, reduces toxic galactitol levels and prevents galactosemia disease complications in vivo.
PC-62883

MK-204

1959605-73-2 MK-204 is a potent, selective AKR1B10 inhibitor with IC50 of 80 nM, shows high selective (270-fold) over AKR1B1.
PC-62882

IDD388

314297-26-2 IDD388 is a potent aldose reductase (ALR2 or AKR1B1) inhibitor with IC50 of 0.4 uM, shows weak inhibition for AKR1B10 (IC50=4.4 uM)..
PC-61992

Fidarestat

136087-85-9 Fidarestat (SNK860) is a potent aldose reductase inhibitor, improves motor nerve conduction velocity (MNCV) and metabolic abnormalities in sciatic nerve were investigated in acute STZ-induced diabetic rats..
PC-45922

Epalrestat

82159-09-9 A noncompetitive and reversible aldose reductase inhibitor with IC50 of 10 nM and 26 nM for purified aldose reductase from rat lens and human placenta, respectively.

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