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Ponalrestat

Chemical Structure : Ponalrestat

CAS No.: 72702-95-5

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Ponalrestat (ICI 128,436, ICI 128436)

Catalog No.: PC-25940Not For Human Use, Lab Use Only.

Ponalrestat (ICI 128436) is a potent, orally active, selective and noncompetitive aldose reductase (AR) inhibitor with Ki of 7 nM (ALR2), inhibits the conversion of glucose to sorbitol.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ponalrestat (ICI 128436) is a potent, orally active, selective and noncompetitive aldose reductase (AR) inhibitor with Ki of 7 nM (ALR2), inhibits the conversion of glucose to sorbitol.

Physicochemical Properties

M.Wt 391.20
Formula C17H12BrFN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid

References

1. Stribling D, et al. Metabolism. 1985 Apr;34(4):336-44.

2. Ward WH, et al. Biochem Pharmacol. 1990 Jan 15;39(2):337-46.

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