Catalog No.: PC-26001Not For Human Use, Lab Use Only.
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
AKR1C3 inhibitor SG-55 is a potent, selective and noncompetitive aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 5 nM, with no inhibition against AKR1C1, AKR1C2, and AKR1C4.
SG-55 elevated the reduced/oxidized nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) ratio, decreased the reduced/oxidized glutathione (GSH/GSSG) ratio, induced DNA double-strand breaks.
SG-55 synergized with Osimertinib to suppress proliferation, clonogenicity, and survival in 19Del/T790M/C797S mutant NSCLC cells.
SG-55 demonstrated efficacy in xenograft models and exhibited favorable pharmacokinetics in mice.
