| Cat. No. |
Product Name |
Information |
| PC-25941 |
Lidorestat
Aldose reductase inhibitor
|
Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with IC50 of 5 nM. |
| PC-25940 |
Ponalrestat
Aldose reductase inhibitor
|
Ponalrestat (ICI 128436) is a potent, orally active, selective and noncompetitive aldose reductase (AR) inhibitor with Ki of 7 nM (ALR2), inhibits the conversion of glucose to sorbitol. |
| PC-25939 |
Zenarestat
Aldose reductase inhibitor
|
Zenarestat (FK-366, FR-74366) is a highly potent, reversible, and mixed type inhibitor of aldose reductase (AR) with IC50 of 3.6 and 4.4 nM for purified AR from the rat sciatic nerve and rat lens. |
| PC-25938 |
Zopolrestat
Aldose reductase inhibitor
|
Zopolrestat (CP73850) is Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with IC50 of 3.1 nM (human placenta AR). |
| PC-25937 |
Tolrestat
Aldose reductase inhibitor
|
Tolrestat (AY-27773) is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. |
| PC-25936 |
Alrestatin
Aldose reductase inhibitor
|
Alrestatin is an inhibitor of aldose reductase with IC50 of 1 uM for human or rat placenta aldose reductase. |
| PC-24479 |
RJG-2051
AKR1C3 inhibitor
|
RJG-2051 is a potent, selective and covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with IC50 of 13 nM, shows clear selectivity against AKR1C1 (2350-fold), AKR1C2 (1790-fold), and AKR1C4 (429-fold). |
| PC-24206 |
Pan-AKR1C inhibitor 29
AKR1C inhibitor
|
Pan-AKR1C inhibitor 29 is a potent, pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor with IC50 of 0.09 μM, 0.28 μM, 0.05 μM, 0.51 μM for AKR1C1, AKR1C2, AKR1C3, and AKR1C4 respectively. |
| PC-24205 |
S07-2010
AKR1C inhibitor
|
S07-2010 is a potent, pan aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 0.19, 0.36, 0.47, and 0.73 uM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively. |
| PC-23116 |
pyrone-211
AKR1C3 inhibitor, GPR84 agonist
|
pyrone-211 is a potent inhibitor of aldo-keto reductase family 1 member C3 (AKR1C3), also is a potent agonist of the semi-orphan receptor GPR84. |
| PC-22474 |
WJ-39
Aldose reductase inhibitor
|
WJ-39 (Darirestat potassium salt) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. |
| PC-22473 |
Darirestat
Aldose reductase inhibitor
|
WJ-38 (Darirestat) is a small molecule aldose reductase (AR) inhibitor, does not affect AR protein expression, reduces oxidative stress by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. |
